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FRUMIL (AMILORIDE, FUROSEMIDE): CLINICAL PHARMACOLOGY

Frumil is a potassium sparing diuretic which combines the potent natriuretic effect of furosemide (frusemide) with the potassium-conserving property of amiloride hydrochloride. The administration of high ceiling diuretics such as furosemide (frusemide) can result in a significant increase in potassium excretion, which may lead to hypokalaemia or metabolic alkalosis. When combined with amiloride, the amount of potassium excreted is decreased and the need for potassium supplements is eliminated. Moreover, the diuresis produced by furosemide (frusemide) is enhanced with amiloride if given in combination.

Furosemide (Frusemide) acts primarily to inhibit electrolyte reabsorption in the ascending limb of the Loop of Henle; this action has also been observed in the proximal tubule.

Excretion of sodium, potassium and chloride ions is increased and water excretion enhanced.

Diuresis is observed within 1 hour of administration and lasts 4-6 hours. Amiloride Hydrochloride acts in the distal convoluted tubule to inhibit the exchange of sodium and potassium ions and therefore to mildly increase the natriuretic effect whilst conserving potassium.

Chloride excretion is little affected by amiloride. Diuresis occurs within 2 hours of administration of amiloride, with peak effect at 6-10 hours; the action lasts for 24 hours.

Clinical studies have indicated that Frumil (Amiloride, Furosemide) consistently maintains plasma potassium levels within the normal range. The diuretic and natriuretic activity of Frumil is greater and more prolonged than furosemide (frusemide) alone. Diuresis was observed within 2 hours and lasted for 24 hours.



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